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antihypertensive agents (Fig. 20). A PDE selective for arterioles should in theory lower blood pressure. Investigation on the pharmacological properties of these molecules suggested that an antagonist to the subtype PDE 5 should prove particularly useful in treating high blood pressure. A research program at P zer led to the discovery of a compound that showed the desired biological action.54 This was taken to the clinic after it had cleared toxicological tests. Although the compound may have proven its value in treating hypertension, its quite unexpected side effect, reversing erectile dysfunction, soon became the main focus of further studies. The compound, sildenfanil, far better known as Viagra, became a bombshell drug once it reached the market. At least two other competitors, vardenfanil and tadala l, have been approved for sale in the United States as of this writing. Although the structures of sildenfanil and vardena l differ only in detail, tadala l has few features in common with them. This difference may be re ected in its much longer duration of action.55

is accomplished through the use of access control lists, trust relationships, inheritance, and delegation of authority. Many of the security ideas adopted by Microsoft for use in Active Directory are part of the X.500 specification. Access Control Lists Users are permitted to use a resource on the network by way of access control lists (ACL), which determine who can use or manipulate another object (resource). ACLs define rights with a level of granularity down to the object attribute and class level. Each ACL is further broken down into access control entries (ACE). ACE provides rights assigned to each user defined in the directory. An example of ACE functionality would be assigning rights to a particular directory on a file server on a Windows 2000 network. Some users or groups of users may have only read access to the directory, where others can read or write to the directory. This access is provided through the ACE and ACL.

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Add dimensions. Constrains offset sketch entities. Instead of the On Edge relations, Offset Entities creates an Offset sketch relation that cannot be re-created manually. Reverse. Changes the direction of the offset. Select chain. Selects continuous end-to-end sketch entities. Bi-directional. Offsets to both sides simultaneously. Make base construction. If you are offsetting sketch entities within the active sketch, this option converts the original sketch entities to construction sketch geometry. Cap ends. Is available only when you have selected the Bi-directional option. Capping the ends with arcs is an easy way to create a slot from a sketch of the centerline. This function works with all sketch entities; it is not limited to straight slots. Figure 3.12 shows examples of the Cap ends option.

Depending on the project size, and whether it is an internal development or an external contract, change management might be less or more formal. If changes require customer approvals, then the change process has to be formalized and described in the plan. In addition, if the project size is very large, change approvals might have to be formalized to keep all team members noti ed and to ensure that the work ow re ects all recent changes. In such formalized situations, the project manager should oversee and mandate the protocols and procedures for the requirement and design change as well as other changes in product development. Requests for changes should be stored in the problem tracking system, prioritized, and then approved or rejected by the team and, if required, other project stakeholders.

Using the triad can be very tricky. Moving the triad in the bending option moves the axis of the bend, and so it determines whether the bend will compress or stretch the material. The position of the triad also determines which side of the bent body will move or stay stationary, or if both sides will move. Placing the triad directly on a trim plane causes the material outside the bend on that side of the trim plane to remain stationary. I highly recommend taking a look at the models that are provided with this chapter to examine the various functions of the Flex feature more carefully. The model uses configurations, which are covered in 10.

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{Simple PaintBar Analysis Demonstrates TradeStation's ability to highlight bars in different market conditions} Inputs: overbought(70),oversold(30),rsiLength(14); Vars: myRsiVal(0); MyRsiVal = RSI(Close,rsiLength); if(myRsiVal>overBought) then PlotPaintBar(High,Low,"RSI",RED); if(myRsiVal<overSold) then PlotPaintBar(High,Low,"RSI",YELLOW);

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