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As with the comparable elicitation of depression from an aberrant electrode in the substantia nigra that was reported by the same group, it is not clear whether the effect was due to changes in adjacent neuronal pathways or whether the physiologic response was excitatory or the result of inhibition of neuronal activity Sex hormones in uence the activity of these temporal lobe circuits; testosterone promotes aggressiveness and estradiol suppresses it, suggesting an explanation for sex differences in the disposition to anger Surprisingly, propranolol and lithium have bene ted such patients more than haloperidol, the phenothiazine drugs, or sedatives Observations in experimental animals have corroborated the observations in humans As mentioned earlier, bilateral removal of the amygdaloid nuclei in the macaque greatly reduces the reactions of fear and anger Electrical stimulation in or near the amygdala of the unanesthetized cat yields a variety of motor and vegetative responses.

The Registry is a database-oriented environment that Microsoft introduced in Windows 95 to make the task of tracking configuration, applications settings, and other system information easier to maintain. The Registry is a large database that exists on all Windows 9x systems and Windows NT systems since Windows NT 4. The Registry keeps track of all settings, user and applications configurations, and other information necessary for the system to function effectively. The Registry interfaces with setup, hardware-oriented programs, administrative tools, device drivers, and the operating system itself. In a nutshell, the Registry is the central repository for all information about the system, as detailed in Figure 8-3. The Registry is read from and written to when the system starts up, when devices are installed, when applications are installed, and when programs are executed. Information such as your desktop preferences, browser configuration, and almost everything else relevant to your system is stored in the Registry. Windows 9x stores Registry information in the system.dat and user.dat files. In Windows 2000 and XP, the Registry is a set of files that typically exist in the system32/config directory of the Windows directory. To make the Registry easier to navigate, it is broken into subsets of data called keys. The Registry keys are accessed either by the program Regedit in Windows 9x or Regedt32 in Windows NT and 2000. The Windows XP Registry editor is Regedit. Regedit appears is similar in function to earlier Registry editors but is a more comprehensive tool. Figure 8-4 shows the five main keys of the Registry in a Windows 2000 system. The Registry editor is not a program listed on the applications shortcuts in a Windows system and must be run

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One of these has been referred to as the fear or ight response, in which the animal appears frightened and runs away and hides; another is the anger or defense reaction, characterized by growling, hissing, and piloerection However, structures other than the amygdaloid nuclei are also involved in these reactions Lesions in the ventromedial nuclei of the hypothalamus (which receive an abundant projection of bers from the amygdaloid nuclei via the stria medullaris and possibly the ventral amygdala fugal pathway) have been shown to cause aggressive behavior, and bilateral ablation of Brodmann area 24 (rostral cingulate gyrus) has produced the opposite state tameness and reduced aggressiveness, at least in some species.

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Rage reactions of the intensity described above may be encountered in the following medical settings: (1) rarely as part of a temporal lobe seizure; (2) as an episodic reaction without recognizable seizures or other neurologic abnormality, as in certain sociopaths; (3) in the course of a recognizable acute neurologic disease; or (4) with the clouding of consciousness that accompanies a metabolic or toxic encephalopathy Each of these circumstances is considered below Rage in Temporal Lobe Seizures (See also page 277) According to Gastaut and colleagues, a directed attack of uncontrollable rage may occur either as part of a seizure or as an interictal phenomenon Some patients describe a gradual heightening of excitability for 2 to 3 days, either before or after a seizure, before bursting into a rage Certainly such attacks have been observed, but they are very rare.

(8.139) (8.140) (8.141) (8.142)

However, a lesser degree of aggressive behavior as part of a temporal lobe seizure is not uncommon; it is usually part of the ictal or postictal behavioral automatism and tends to be brief in duration and poorly directed Usually the lesion is in the temporal lobe of the dominant hemisphere Similarly, a feeling of rage or severe anger occurs but is relatively infrequent.

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