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199 This statement requires that each signi cant assumption used in determining the bene t information re ect the best estimate of the plan s future experience solely with respect to that assumption That method of selecting assumptions is referred to as an explicit approach An implicit approach, on the other hand, means that two or more assumptions do not individually represent the best estimate of the plan s future experience with respect to those assumptions Rather, the aggregate effect of their combined use is presumed to be approximately the same as that of an explicit approach The Board believes that an explicit approach results in more useful information

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well-being after oral administration of 50 mg DHEA/day [52], or in improvement of ED in impotent men [53]

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cash received by syndicators should be allocated to unpaid syndication fees before being allocated to the initial and continuing investment After the syndication fee is fully paid, additional cash received should rst be allocated to unpaid fees for future services, to the extent those services have been performed by the time the cash is received, before being allocated to the initial and continuing investment (j) ALTERNATE METHODS OF ACCOUNTING FOR SALES As previously discussed, in some circumstances the accrual method is not appropriate and other methods must be used It is not always clear which method should be used or how it should be applied Consequently, it is often dif cult to determine the appropriate method and whether alternative ones are acceptable The methods prescribed where the buyer s initial or continuing investment is inadequate are the deposit, installment, cost recovery, and reduced pro t methods The methods prescribed for a transaction that cannot be considered a sale because of the seller s continuing involvement are the nancing, lease, and pro t sharing (or co-venture) methods (i) Deposit Method When the substance of a real estate transaction indicates that a sale has not occurred, for accounting purposes, as a result of the buyer s inadequate investment, recognition of the sale should be deferred and the deposit method used This method should be continued until the conditions requiring its use no longer exist For example, when the down payment is so small that the substance of the transaction is an option arrangement, the sale should not be recorded All cash received under the deposit method (including down payment and principal and interest payments by the buyer to the seller) should be reported as a deposit (liability) An exception is interest received that is not subject to refund may appropriately offset carrying charges (property taxes and interest on existing debt) on the property Note also the following related matters:.

Growth Hormone (GH) and insulin-like growth factor (IGF-1)

Notes receivable arising from the transaction should not be recorded The property and any related mortgage debt assumed by the buyer should continue to be

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It has been proven that GH and IGF-1 affect penis growth and androgen production [54] In cases with isolated GH de ciency and micropenis, continuous treatment with recombinant growth hormone normalizes the penile size [54] Recently it has been suggested that GH also plays a role in erection [55] Recombinant GH caused dose-dependent relaxation of cavernous smooth musculature by increasing intracellular cGMP levels During erection a 90% increase in intracavernous GH concentration occurred in the tumescence stage

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