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Although we sometimes say that the glomerular filtrate is protein-free, it is not truly free of all protein First, small and medium-size proteins (eg, angiotensin, insulin) are filtered in considerable quantities Second, although the movement of large plasma proteins across glomerular filtration barrier is extremely limited, a small amount does make it through into Bowman s space For albumin, the plasma protein of highest concentration in the blood, the concentration in the filtrate is normally about 10 mg/L, or roughly 002% of the plasma albumin concentration (50 g/L) Yet because of the huge volume of fluid filtered per day, the total filtered amount of protein is not negligible However, the proximal tubule is capable of taking up filtered albumin and other proteins, and we treat this protein uptake separately here to emphasize its importance We use the word uptake rather than reabsorption because the proteins, although they are transported intact out of the lumen into the epithelial cells, are degraded into their constituent amino acids before being transported into the cortical interstitium Thus, the term reabsorption in the context of proteins and peptides, although widely used, is actually a misnomer The initial step for the uptake of larger proteins is endocytosis at the luminal membrane This energy-requiring process is triggered by the binding of filtered

Simplicity is a form of humility, and simplicity is a sign of true greatness Meekness is a sign of humility, and meekness is a sign of true strength

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once coverage is reestablished, as well as support for multiple networks Assisted by Zamba Inc, an independent contractor working with Andersen Consulting, which consulted on the project, BellSouth chose Broadbeam s ExpressQ mobile messaging middleware The new middleware solution provided a new level of communications security In 98, we had another major change: a new middleware provider; and a new wireless modem provider," Dennis recalled Initially we had bought Motorola modems with our Itronix laptop purchases, but Motorola decided to get out of that business So in 98, after having done the pilot and bought five or six hundred Motorola modems for the laptops, we changed over to RIM and its wireless modem capability We bought enough RIM technology for 15,000 technicians in 1999" The entire TechPlus implementation cost $163 million to provide the technicians with both wireline and wireless connectivity to their home bases Initial capabilities for the network included on-the-fly dispatch, receiving and closing out trouble tickets in real-time, and completing work orders Technicians also gained immediate mobile access to existing BellSouth computer systems for network testing, work assignments, maintenance, and customer information Today, as many as 58,000 wireless transactions per hour are piped through the system, which is entirely IP-based in the back end

reNaL haNDLING OF OrGaNIC SUBStaNCeS / 67

Humility, as I want to use the word, is the quality of being unpretending The humility Lombardi is talking about is giving credit where credit is due If you did it, take the credit If you had help, recognize those who helped you For a leader, humility is the recognition that you get results only through the efforts of others It is yet another way of embodying truth and reinforcing character There are two senses in which humility bears on leadership The first is simply in understanding that even the most powerful of leaders is only a bit player on the larger stage of life

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Keep in mind that there are laws independent of man s consent, ruling over reality, over nature, over man, too, whether he be willing to recognize them or not to which we must bow, unless we think we can rule ourselves independently of the rest of nature Egoism, in other words, must be defeated in self The egoist is never happy

BellSouth s fleet of more than 15,000 customer service vans has been equipped with battery charging stations for the Itronix notebook computers, as well as HIGH-gain antennas and full-sized computer printers The network utilizes multiple Windows NT Servers running the ExpressQ middleware, providing redundancy and the ability to scale In all," Dennis said, our transaction times are faster and we have reduced network transaction time an average of 48 minutes a day per technician, which has been scientifically tracked," he said We ve reduced the number of log-ins and that should translate into productivity gains" However, BellSouth Telecommunications, like many other phone companies in transition, has experienced huge technician turnover as many as 8,000 of the 15,000 technicians on the job are brand new since the wireless data network went live This has confounded research on productivity; since technicians must learn on-the-job skills before productivity increases are fairly assessed

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