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One stochastic process that is particularly useful for modeling purposes is white noise The adjective white indicates that this particular type of noise has constant power at all frequencies Any process that does not have equal power per frequency interval will be referred to as colored Because power distribution per frequency interval is the distinguishing factor, for both continuous-time and discrete-time white noise, our discussion will start from the PSD

tell the application id "comappleitunes" with timeout of 1200 seconds try end try end timeout end tell

124 4421

track in the Library whose rating is 60 that is, three stars The new statement appears in boldface here:

A scalar continuous-time random process v(t) is referred to as a white noise process if its PSD is constant:

tell the application id "comappleitunes" with timeout of 1200 seconds try set three_star_songs to every track of playlist "Library" whose rating is 60 end try end timeout end tell

2 Rv (t) = v ( )

(436)

three_star_songs list, as shown in boldface here:

where ( ) is the Dirac delta function: ( ) = lim ( ) =

tell the application id "comappleitunes" with timeout of 1200 seconds try set three_star_songs to every track of playlist "Library" whose rating is 60 repeat with this_song in three_star_songs end repeat end timeout end tell

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atinocyte synthesis of AP-1 and matrix metalloproteinases (MMPs)106,107 Keratinocyte growth factor (KGF, FGF-7) is one of the 22 members of the broblast growth factor family112 KGF, synthesized by broblasts, acts as a paracrine growth factor that induces keratinocyte proliferation113,114 Synthesis of KGF is enhanced by proin ammatory cytokines, interleukin (IL)-1 , IL-1 , and TNF113 KGF has signi cant effects on epidermal keratinocyte migration during wound repair, but its application in topical preparations has been limited by its short biologic half-life112 Newer approaches in wound management have used KGF by covalently attaching the growth factor to peptides that are cleaved by products of matrix metabolism during wound repair Cleavage of the covalent bond releases KGF directly into tissue as a bioactive substrate capable of stimulating keratinocyte proliferation and migration112,114 Bioengineered KGFpeptide complexes applied to wounded cutaneous tissue allow for a gradual and persistent release of KGF and result in signi cantly reduced epidermal wound closure time112 Because of its short biologic half-life, KGF applications should employ mechanisms that ensure ongoing secretion of KGF This can be achieved by application of tissue products capable of synthesizing KGF, or those that contain an altered form of KGF that is slowly released into as a tissue-available substrate As with other peptides, research into wound healing resulted in extrapolation of data to justify the use of growth factors in cosmeceuticals The science of wound healing and the effects of large molecules to speed healing do not necessarily translate into effectiveness of penetration into intact dermis for biologic effect Clinical bene t has been documented, however, and justi es the use of these ingredients in cosmeceutical formulas for photoaged skin (Figure 35)

1 which has units of sec An implication of eqn (436) is that E v(t) = 0 Nevertheless, problem assumptions will often state the fact that v(t) is a 2 zero mean, continuous-time, white noise process with PSD v The fact that the spectral density is a constant function highlights the fact that continuous-time white noise processes are not realizable All continuous-time white noise processes have in nite power, as demonstrated by eqn (435):

(continued)

v 2 (t)dt = Rv (0)

details of the current song, which is represented by the this_song variable The new statement appears in boldface here:

1 2 1 2

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