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qinghaosu research from the different disciplines of botany, chemistry, pharmacology, and clinic medicine during the last two decades. Undoubtedly, the discovery of qinghaosu is one of the most important achievements for the natural products chemistry during the last two decades of the twentieth century. It may be recognized as a milestone in the progress of natural products chemistry in comparison with quinine in the nineteenth century. Qinghaosu is also a star molecule just like Taxol in about the same period. For the modernization of traditional Chinese medicine, qinghaosu is also one of the most successful examples. This chapter intends to describe its structure determination, reaction, and synthesis. The congeneric natural products in qinghao are also mentioned. This chapter will review the progress in the search for derivatives of qinghaosu, the chemical biology study, and the exploration on the action mode. Because of the limitation of the volume and the massive publications on this subject, this chapter will preferentially, rather than comprehensively, introduce the progress achieved in China. 5.2 QINGHAOSU AND QINGHAO (ARTEMISIA ANNUA L. COMPOSITES) 5.2.1 Discovery and Structure Determination of Qinghaosu

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[ ( RP i RP ) ( RM j RM ) ] Covariance = -----------------------------------------------------------------------------N

Let s take a closer look at the role of those Web services standards and technologies and how they are represented in Web services architecture and its development process.

The big Web Services story is the end-to-end, side-to-side integration of technology. James Gosling, The father of Java Platform

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In studying the effects of the above-mentioned modes of interference it is necessary to consider the following worst-case propagation conditions over the interference paths:

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by substituting (10.9) into (10.2). Finally, the relationship between the forward rate and the short rate is: f(t, t) = r(t) (10.11)

Axis allows service clients to be created in two different ways: 1. Having the required values for locating and invoking the service provider, such as SOAP, endpoint of the service, methods, parameters, and so on 2. Using a WSDL-based service description exposed by the service provider Now, let s take a look at the programming steps involved in creating the service client with all of the required parameters and how to invoke the service exposed by the provider.

is independent of the maturity T. Then the zero-coupon bond price must satisfy a bond pricing PDE (P = P(r, t, T)): P P 1 2 2 P + + (r , t ) = rP r t 2 r 2 subject to: P(r, T, T) = 1 The solution to this bond pricing equation is given by the Feynman-Kac formula: T P(t , T ) = EtQ exp r (u)du t (10.20)

Medicinal Chemistry of Bioactive Natural Products Edited by Xiao-Tian Liang and Wei-Shuo Fang Copyright # 2006 John Wiley & Sons, Inc.

http://www.python.org http://www.pythonlabs.com (Community home page) (Commercial home page)

If your intention is to add data to a file or simply avoid overwriting existing data, you can append output to an existing file (called nondestructive redirection). The syntax is as follows:

where now, in continuous time, F(t, T) is the instantaneous forward rate at time t for maturity at time T. q(t, T) is the qth component of the volatility of F(t, T). Equation (13.8) is the HJM model, which, as we see, is a limiting case of the LIBOR market model.

E[ X] =

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