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damaging) stimuli One type is the very ne, unmyelinated, slowly conducting C ber (03 to 11 m in diameter); the other is the thinly myelinated, more rapidly conducting A-delta (A- ) ber (2 to 5 m in diameter) The peripheral terminations of both these primary pain afferents or receptors are the free, profusely branched nerve endings in the skin and other organs; these are covered by Schwann cells but contain little or no myelin There is considerable evidence, based on their response characteristics, that a degree of subspecialization exists within these freely branching, nonencapsulated endings and their small ber afferents Three broad categories of free endings or receptors are recognized: mechanoreceptors, thermoreceptors, and polymodal nociceptors Each ending transduces stimulus energy into an action potential in nerve membranes The rst two types of receptors are activated by innocuous mechanical and thermal stimulation, respectively; the mechanoeffects are transmitted by both A- and C bers and the thermal effects mostly by C bers The majority of C bers are polymodal and are most effectively excited by noxious or tissue-damaging stimuli, but they can respond as well to both mechanical and thermal stimuli and to chemical mediators such as those associated with in ammation Moreover, certain A- bers respond to light touch, temperature, and pressure as well as to pain stimuli and are capable of discharging in proportion to the intensity of the stimulus The stimulation of single bers by intraneural electrodes indicates that they can also convey information concerning the nature and location of the stimulus These observations on the polymodal functions of A- and C bers would explain the earlier observations of Lele and Weddell that modes of sensation other than pain can be evoked from structures such as the cornea, which is innervated solely by free nerve endings The manner in which painful stimuli are translated into electrical depolarizations in nerve endings are beginning to be understood A number of specialized molecules, when activated by noxious stimuli, open cationic channels in membranes of the nerve ending Opening of these channels, in turn, activates voltage-gated sodium channels and generates an action potential in the sensory axon The regulation and activation of these receptor molecules is summarized by Mannion and Woolf The peripheral afferent pain bers of both A- and C types have their cell bodies in the dorsal root ganglia; central extensions of these nerve cells project, via the dorsal root, to the dorsal horn of the spinal cord (or, in the case of cranial pain afferents, to the nucleus of the trigeminal nerve, the medullary analogue of the dorsal horn) The pain afferents occupy mainly the lateral part of the root entry zone Within the spinal cord, many of the thinnest bers.

Table 8-1 Classi cation and function of sensory peripheral nerve ber types and symptoms associated with intrinsic dysfunction of each type

Remotely manage the power state of the systems Display the hardware configuration of the system Monitor the hardware for faults and receive alerts about system events as they occur Remotely access the command line and the GUI consoles of the host, and perform management functions as if you were using a locally attached keyboard, video, and mouse Observe the status of various system sensors and indicators

ALTERNATIVE FIBER TYPE DESIGNATION FIBER DIAMETER CONDUCTION VELOCITY (M/S) FUNCTION AND SYMPTOMS OF DYSFUNCTION

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read/write head The read/write heads all move as a single unit back and forth along the stack Hard drives are available in a wide range of capacities and can hold much more data than a floppy disk Most new hard drives have a capacity between 30GB and 120GB The disk must be divided into smaller units, called clusters, before it can store data This division is accomplished through formatting Depending on the capacity and file system used, each cluster can hold between 512B to 32KB of data Data storage and file systems are discussed in more detail in s 8 and 9

A-alpha and beta Large, heavily myelinated A-gamma A-delta Small, thinly myelinated B C Small, unmyelinated; polymodal

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