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The relatively nondiscriminating nature of this collection of transporters accounts for their ability to eliminate from the body so many drugs and other foreign environmental chemicals In this regard, the liver s metabolic transformations are very important In the liver, many foreign (and endogenous) substances are conjugated with either glucuronate or sulfate The addition of these groups then renders the parent molecule far more water soluble These 2 types of conjugates are actively transported by the organic-anion secretory pathway The most intensively studied organic anion secreted by this pathway is paraaminohippurate (PAH), the substance used for the measurement of effective renal plasma flow (see 3) PAH secretion involves a pair of antiporters, one at each membrane At the basolateral membrane, PAH is taken up in exchange for the anion (base) form of a dicarboxylic acid PAH is extruded into the lumen across the apical membrane via another antiporter As the plasma concentration of an anion secreted by this system increases, so does the rate of secretion (until the Tm for that substance is reached) This provides a mechanism for homeostatically regulating the endogenous organic anions handled by the system and for speeding the excretion of foreign organic anions PAH is typical, in yet another way, of many of the organic anions secreted proximally: It undergoes no significant additional transport anywhere along the nephron In contrast, some of the other organic anions secreted by the proximal tubule can also undergo other forms of transport in both the proximal tubule and more distal segments The most important of these is passive tubular reabsorption or secretion, which is described later pdf compression library c# How to reduce PDf File size when upload it? - C# Corner
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C# ( PDF Compression ) Big PDF file to Small PDF . Can you help me. Urate (the base form of uric acid) provides a fascinating example of the renal handling of organic anions that is particularly important for clinical medicine and is illustrative of renal pathology An elevated plasma concentration of urate can cause gout; therefore, its removal from the blood is important However, it is as though the kidney cannot make up its mind what to do with urate Urate is not protein bound and so is freely filterable Almost all the filtered urate is reabsorbed early in the proximal tubule; however, further on in the proximal tubule, urate undergoes active tubular secretion Then, in the straight portion, urate is once again reabsorbed The total rate of tubular reabsorption is normally much greater than the rate of tubular secretion, and so the mass of urate excreted per unit time is only a small fraction of the mass filtered We will not discuss the specific transport steps required to accomplish all of this, but most involve antiporters that exchange urate for another organic anion Although urate reabsorption is greater than secretion, the secretory process is homeostatically controlled to maintain relative constancy of plasma urate In other words, if plasma urate begins to increase because of increased urate production, the active proximal secretion of urate is stimulated, thereby increasing urate excretion Given these mechanisms of renal urate handling, the reader should be able to deduce the 3 ways by which altered renal function can lead to decreased urate reduce pdf file size in c# How to Compress PDF Document in C# , VB.NET - E-iceblue
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Using iTextSharp is possible you need to set the version of PDF and then, try this ... string pdfFile = @"D:\Test. pdf "; PdfReader reader = new ... . W H AT I T TA K E S T O B E # 1 70 / 5 We set out to write this book in order to deliver a definitive blueprint for thinking about and implementing technologies required to go wireless," helping enterprises extend their knowledge flows to encompass mobile workers, customers, and suppliers, and to develop new models for profit and selective data exchange We believe that this book will help corporate managers develop a sense of what is possible with wireless today to tailor personalized data for users while selecting wireless devices, gateways and networks It will show the technical reader how to implement wireless applications that enable disruptive market strategies and new methods for generating revenue, linking enterprise assets securely with people using laptops, personal digital assistants (PDAs) smart phones, palmtops, dashboards, and other varying flavors of mobile devices Most importantly, the book provides a reality check for controversial claims about wireless For the management reader, it uncovers what can be accomplished effectively today in both the business and consumer space using existing applications and networks and outlines the most immediate possibilities for a fully untethered enterprise and lifestyle tomorrow It guides a reader on a journey beyond the Internet and simple cellular systems to a world of wireless knowledge driving the enterprise to new levels of performance, mobile e-commerce, and customer satisfaction Wireless Data For The Enterprise: Making Sense of Wireless Business starts out in One, A Day in the Life of Mobile She Devil," by describing a futuristic view of how wireless data will touch every aspect of our lives from home monitoring, to wireless coupons, to email access, to news alerts, to wireless business applications The chapter concludes by looking at the trends effecting the implementation and effectiveness of wireless applications To provide a backdrop for our discussion, Two Needed and Do-Able: A Wireless Data History," walks readers through the early development of wireless data communications, from ancient smoke signals to today s wireless data networks, showing the acceleration of the development cycle and how needs drive technology Then we explore how new drivers are pushing the growth of wireless business applications Three, Untethered Enterprise: No Pain, No Gain," outlines lessons learned by early enterprise adopters and outlines questions to ask yourself to deterXIX. compress pdf file size in c# Compress existing PDF using C# programming using freeware ...
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