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The following points should be kept in mind when calculating an inbreeding coef cient: 1. All possible paths must be counted. A path is possible if gametes can actually pass in that direction. Paths that violate the rules of inheritance cannot be used. For example, in gure 19.4, the following path is unacceptable: I G E A D H I. 2. In any path, an individual can be counted only once. 3. Every path must have one and only one common ancestor. The inbreeding coef cient of any other individual in the path is immaterial. In gure 19.6, we present a complex pedigree produced from repeated sib mating, a pattern found in livestock and laboratory animals. This pedigree has two interesting points. First, common ancestors occur in several different generations. Second, some of the paths are complex. Thus, we must be sure to count all paths (paths 5 and 6 might not be immediately obvious). Although not shown in gure 19.6, one of the common ancestors, A, is also inbred (FA 0.05) a fact that we must take into consideration in paths 3 and 5. Thus, FI is as follows: From path 1: (1/2)3 From path 2: (1/2)

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1517 Verify that the transfer characteristic of Figure 1542 is correct 1518 For the comparator circuit shown in Figure 1562, sketch the waveforms vout (t)

3 5 5 5 5

This equation accounts only for the inbreeding of I by the path involving the common ancestor, A, and does not account for the symmetrical path with B as the common ancestor. To obtain the total probability of inbreeding, the values from each path must be added (because these are mutually exclusive events; see chapter 4). Thus the complete formula for the inbreeding coef cient of the offspring of rst cousins is FI [(1 2) (1

+ v (t) ~ S _

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As temperature variations can affect the accuracy of a process [20, 22], manufacturing engineers must pay attention to these variations when there is a need for accuracy and precision The thermal expansion of the components of a machine tool, which causes distortion, is an important factor that controls the precision of a machine tool The sources of heat may originate internally such as in bearings; machine ways, motors, and heat generated from the cutting zone, or may be external, such as from nearby furnaces, heaters, sunlight, and fluctuations in cutting and ambient temperature [6] The use of high-speed machining spindles with a coolant supply such as the one shown in Figure 131 is desirable [21] These considerations are particularly important in precision and ultra-precision machining, including diamond turning, where dimensional tolerances and surface finish have to necessarily be in the nanorange

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1519 Derive the expressions for the switching thresholds of the Schmitt trigger of Figure 1548 1520 Explain why positive feedback increases the switching speed of a comparator 1521 Compute the period of the square wave generated by the multivibrator of Figure 1553 if C = 1 F, R1 = 10 k , R3 = 100 k , and R2 = 1 k 1522 Compute the value of R3 that would increase the duration of the one-shot pulse

1523 Compute the value of C that would increase the duration of the one-shot pulse in Example 1514 to 10 ms

(19.1)

Fig 131:

in which FI is the probability that the two alleles in I are identical by descent, n is the number of ancestors in a given path, FJ is the inbreeding coef cient of the common ancestor of that path, and all paths are summed. In the example of the mating of rst cousins ( g. 19.4) FI (1 2)5(1 FA ) (1 2)5(1 FB )

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