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There may be up to ten or even more loose stools per day, often accompanied by abdominal cramps and nausea, occasionally by vomiting, and rarely by fever The stools are usually watery and not associated with fever when caused by entertoxigenic E coli With invasive bacterial pathogens (Shigella, Campylobacter, Salmonella) stools can be bloody and fever may be present The illness usually subsides spontaneously within 1 5 days, although 10% remain symptomatic for 1 week or longer, and symptoms persist for longer than 1 month in 2% Traveler s diarrhea is also a significant risk factor for developing irritable bowel syndrome

public override void Read( )

For most individuals, the affliction is short-lived, and symptomatic therapy with opioids or loperamide is all that is required, provided the patient is not systemically ill (fever 39 C) and does not have dysentery (bloody stools), in which case antimotility agents should be avoided Packages of oral rehydration salts to treat dehydration are available over the counter in the United States (Infalyte, Pedialyte, others) and in many foreign countries

DuPont HL Azithromycin for the self-treatment of traveler s diarrhea Clin Infect Dis 2007 Feb 1;44(3):347 9 [PMID: 17205439]

In patients with fever and bloody diarrhea, stool culture is indicated, but in most cases, cultures are reserved for those who do not respond to antibiotics

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To illustrate the implications of marking an implementing method as virtual, the Run( ) method calls the Read( ) and Write( ) methods in four ways: Through the Note class reference to a Document object Through an interface reference created from the Note class reference to the Document object Through a Document object Through an interface reference created from the Document object Virtual implementations of interface methods are polymorphic, just like the virtual methods of classes.

Hill D R et al The practice of travel medicine: guidelines by the Infectious Disease Society of America Clin Infect Dis 2006 Dec 15;43(12):1499 539 [PMID: 17109284] Thielman NM et al Clinical practice Acute infectious diarrhea N Engl J Med 2004 Jan 1;350(1):38 47 [PMID: 14702426]

Specific steps (outlined below) are required when considering antibiotic therapy for patients Drugs within classes, drugs of first choice, and alternative drugs are presented in Tables 30 4, 30 5, 30 6, 30 7, and 30 8

Based on the organ system involved, the organism causing infection can often be predicted See Tables 30 9 and 30 10

Over the past 10 years, pharmaceutical companies have shifted away from developing and producing antibacterial medications Consequently, few new agents, particularly those active against gram-negative pathogens, are expected The lack of new drugs and increasing bacterial resistance reinforce the need to use these drugs judiciously Antimicrobial drug susceptibility tests may be performed on solid media as disk tests, in broth in tubes, in wells of microdilution plates, or as E-tests (strips with increasing concentration of antibiotic) The latter three methods yield results expressed as MIC (minimal inhibitory concentration), and the broth and microdilution techniques can be modified to give MBC (minimal bactericidal concentration) results In most infections, the MIC is the appropriate in vitro test to guide selection of an antibacterial agent When there appear to be marked discrepancies between susceptibility testing and clinical response, the following possibilities must be considered: 1 Selection of an inappropriate drug, drug dosage, or route of administration 2 Failure to drain a collection of pus or to remove a foreign body 3 Failure of a poorly diffusing drug to reach the site of infection (eg, central nervous system) or to reach intracellular phagocytosed bacteria 4 Superinfection in the course of prolonged chemotherapy 5 Emergence of drug-resistant organisms 6 Participation of two or more microorganisms in the infectious process, of which only one was originally detected and used for drug selection 7 Inadequate host defenses, including immunodeficiencies and diabetes 8 Noninfectious causes, including drug fever, malignancy, and autoimmune disease

When you call the nonpolymorphic Write( ) method on the IStorable interface cast from the derived Document, you actually get the Note s Write method, because Write( ) is implemented in the base class and is nonvirtual. To see polymorphism at work with interfaces, you ll create a reference to the Note class and initialize it with a new instance of the derived Document class:

have undesirable effects on cardiac conduction Neither the weakness nor the course of the disorder is influenced by treatment

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