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Pheochromocytomas are tumors that arise from the adrenal medulla, while paragangliomas ( extra-adrenal pheochromocytomas ) are related tumors that arise from sympathetic paraganglia These tumors are a rare cause of hypertension, being found in less than 03% of hypertensive individuals The incidence is higher in patients with moderate to severe hypertension About two new cases per million population are diagnosed annually However, in autopsy cases, the incidence

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Some patients are normotensive and asymptomatic Others presenting symptoms and signs include psychosis or confusion, seizures, hyperglycemia, bradycardia, hypotension, constipation, paresthesias, or Raynaud s phenomenon Physical findings usually include hypertension (90% of patients), which may be sustained (20% of patients), sustained with paroxysms (50% of patients), or paroxysmal only (25% of patients) There may be cardiac enlargement and cardiomyopathy, postural tachycardia (change of more than 20 beats/min) and postural hypotension, and mild elevation of basal body temperature Retinal hemorrhage or cerebrovascular hemorrhage occurs occasionally Catastrophic hypertensive crisis and fatal cardiac arrhythmias can occur spontaneously or may be triggered by intravenous contrast dye or glucagon injection, needle biopsy of the mass, anesthesia, and surgical procedures In addition to catecholamines and their metabolites, pheochromocytomas secrete a wide range of other peptides that can sometimes cause symptoms of Cushing s syndrome (ACTH), erythrocytosis (erythropoietin), or hypercalcemia (PTHrP)

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of pheochromocytoma is 250 1300 cases per million, indicating that most cases are not diagnosed during life The hypertension is caused by excessive plasma levels of norepinephrine or neuropeptide Y The tumor is located in either or both adrenals or anywhere along the sympathetic nervous chain, and rarely in such aberrant locations as the thorax, bladder, or brain Pheochromocytomas are characterized by a rough rule of tens : About 10% of cases are not associated with hypertension; 10% of cases are extra-adrenal, and of those about 10% of cases are extra-abdominal; 10% of cases occur in children In about 10% of cases, the tumor involves both adrenal glands (bilateral adrenal tumors tend to occur more frequently in familial cases); and about 10% of cases have metastatic disease noted around the time of diagnosis Initially occult metastases are later discovered in another 5% of cases Familial pheochromocytomas are usually bilateral (70% of cases) but may present as unilateral pheochromocytoma with a contralateral pheochromocytoma appearing years later; they may be associated with the following: calcitoninsecreting medullary thyroid carcinoma and hyperparathyroidism (MEN type 2), medullary thyroid carcinoma and the syndrome of multiple mucosal neuromas (MEN type 2B), sussinate dehydrogenase gene mutations (see below), neurofibromatosis (Recklinghausen s disease), and islet cell tumors (rare) Pheochromocytomas develop in about 20% of patients with von Hippel Lindau disease (hemangiomas of the retina, cerebellum, brainstem, and spinal cord; pancreatic cysts; renal cysts, adenomas, and carcinomas); inheritance is autosomal dominant Familial paragangliomas arise in patients harboring pathologic sequence variants in the succinate dehydrogenase gene subunits: SDHB, SDHC, and SDHD Multiple paragangliomas typically arise at an early age and are often malignant Only about 10% of affected patients have a family history of pheochromocytoma or paraganglioma However, family histories are unreliable and phenotypic penetrance is variable About 20 30% of these patients harbor germline mutations, making such patients prone to development of additional tumors.

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To make this work properly, you must cast the constant to its underlying type (int). In this case, you are saying, Treat this enumerated constant as an int. Because you know the underlying type is int, this is safe to do. (See Casting earlier in this chapter.) In Example 3-5, the values in the two enumerated constants FreezingPoint and BoilingPoint are both cast to type int; then that integer value is passed to WriteLine( ) and displayed. Each constant in an enumeration corresponds to a numerical value. In Example 3-5, each enumerated value is an integer. If you don t specifically set it otherwise, the enumeration begins at 0 and each subsequent value counts up from the previous. Thus, if you create the following enumeration:

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