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In a real-world application, you would almost certainly mark both methods as virtual, but we ve differentiated them to demonstrate that the developer is free to pick and choose which methods are made virtual.

Disorder Duchenne type Inheritance X-linked recessive Age at Onset (years) 1 5 Distribution Pelvic, then shoulder girdle; later, limb and respiratory muscles Pelvic, then shoulder girdle Pelvic or shoulder girdle initially, with later spread to the other Face and shoulder girdle initially; later, pelvic girdle and legs Humeroperoneal or scapuloperoneal Onset distally in extremities; proximal involvement later External ocular muscles; may also be mild weakness of face, neck, and arms As in the ocular form but with dysphagia Face, neck, distal limbs Slow progression 14q112 q13 19q132q133; 3q213 Prognosis Rapid progression Death within about 15 years after onset Slow progression May have normal life span Variable severity and rate of progression Possible severe disability in middle life Slow progression Minor disability Usually normal life span Variable Slow progression Genetic Locus Xp21

5 25 10 30

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X-linked recessive or autosomal dominant Autosomal dominant or recessive Autosomal dominant (may be recessive) Autosomal dominant Autosomal dominant

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5 10 40 60 Any age (usually 5 30) Any age Any age (usually 20 40)

specimen may help confirm that weakness is due to a primary disorder of muscle and to distinguish between various muscle diseases A genetic defect on the short arm of the X chromosome has been identified in Duchenne dystrophy The affected gene codes for the protein dystrophin, which is markedly reduced or absent from the muscle of patients with the disease Dystrophin levels are generally normal in the Becker variety, but the protein is qualitatively altered Duchenne muscular dystrophy can now be recognized early in pregnancy in about 95% of women by genetic studies; in late pregnancy, DNA probes can be used on fetal tissue obtained for this purpose by amniocentesis The genes causing some of the other muscular dystrophies are listed in Table 24 8 There is no specific treatment for the muscular dystrophies, but it is important to encourage patients to lead as normal lives as possible Prednisone (075 mg/kg daily) improves muscle strength and function in boys with Duchenne dystrophy, but side effects need to be monitored Prolonged bed rest must be avoided, as inactivity often leads to worsening of the underlying muscle disease Physical therapy and orthopedic procedures may help counteract deformities or contractures

Kirschner J et al The congenital and limb-girdle muscular dystrophies Arch Neurol 2004 Feb;61(2):189 99 [PMID: 14967765] Moxley RT 3rd et al Practice Parameter: Corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Neurology 2005 Jan 11;64(1):13 20 [PMID: 15642897] Tawil R et al Facioscapulohumeral muscular dystrophy Muscle Nerve 2006 Jul;34(1):1 15 [PMID: 16508966]

It is not necessary for Document to override Read( ), but it is free to do so and has done so here:

Usually a benign, self-limited disease occurring about 1 week into travel Prophylaxis not recommended unless there is a comorbid disease (inflammatory bowel syndrome, HIV, immunosuppressive medication) Single-dose therapy of a fluoroquinolone usually effective if symptoms develop

Whenever a person travels from one country to another particularly if the change involves a marked difference in climate, social conditions, or sanitation standards and facilities diarrhea may develop within 2 10 days Bacteria cause 80% of cases of traveler s diarrhea, with enterotoxigenic E coli, Shigella species, and Campylobacter jejuni being the most common pathogens Less common are Aeromonas, Salmonella, noncholera vibriones, E histolytica, and G lamblia Contributory causes include unusual food and drink, change in living habits, occasional viral infections (adenoviruses or rotaviruses), and change in bowel flora Chronic watery diarrhea may be due to amebiasis or giardiasis or, rarely, tropical sprue

This chapter has given you a brief look at Jaguar, Apple s first major upgrade to Mac OS X. In many ways, Jaguar extends the current system, but it also adds many new features and enhancements. For UNIX developers, this means gcc v3.1, FreeBSD4.4 compatibility, additions to the existing developer tools such as Project Builder and Interface Builder, and new features in the Terminal application. Perl programmers can now take advantage of the Cocoa Foundation through PerlObjCBridge, which gives you access to Cocoa objects and features from Perl modules. Jaguar is a significant step forward for Mac OS X. For UNIX developers and users, there is a lot to like.

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