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in which pn is the increment of a alleles added by forward mutation, and qn is the loss of a alleles due to back mutation. Equation 20.1 takes into account not only the rate of forward mutation, , but also pn, the frequency of A alleles available to mutate. Similarly, the loss of a to A alleles is the product of both the rate of back mutation, , and the frequency of the a allele, qn. Equation 20.1 completes the second modeling step, derivation of an expression for qn 1, allelic frequency after one generation of mutation pressure. The third step is to derive an expression for the change in allelic frequency between two generations.This change ( q) is simply the difference between the allelic frequency at generation n 1 and the allelic frequency at generation n. Thus, for the a allele q qn

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presence of noise with peak amplitude = 150 mV The circuit is to switch around the reference value 1 V Assume an op-amp with 10-V supplies (Vsat = 85 V)

1567 In the circuit of Figure P1567, R1 = 100 ,

(20.2)

xed time intervals Such a device is called a real-time clock and is used in control applications to establish the sample period as T seconds for control algorithms Show how this can be done with a square wave (clock) that has a period equal to the desired time interval between interrupts

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The design procedure for an aerostatic thrust bearing is quite similar to that of the aerostatic journal bearing The design of the aerostatic thrust bearings requires a compromise between the conflicting demands of performance, the available gas supply and the manufacturing capability The load capacity, stiffness and gas flow can be estimated by reference to Figure 761 and Figure 762 The data are presented for a supply pressure gauge of 100 lbf/in2 and atmospheric exhaust conditions The standard clearance of 00005 in is the same as that for the journal bearings For Figure 761 and 762, the load capacity is given at the point of maximum stiffness (Kg = 069) Example: Design of Thrust Bearing Two thrust bearings are used to provide the ability to carry load in both directions The thrust bearings support the grinding spindle of a machine The parameters are introduced as follows: Thrust Load = 120 lbf 534 N Axial Stiffness = 800 000 lbf/in 140 000 N/mm 517 kPa Air Supply Pressure = 75 lbf/in2 Airflow = 065 scfm 00184 m3/min Outer Diameter = 3 in 762 mm Central Hole Diameter = 1 in 254 mm Figure 759 shows the aerostatic work and grinding spindles of a Toshiba ultra-precision grinding machine Both the spindles require thrust bearings, as aerostatic journal bearings are not capable of

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(20.3)

R2 = 56 k , Ri = R1 R2 , and vin is a 1-V peak-to-peak sine wave Assuming that the supply voltages are 15 V, determine the threshold voltages (positive and negative v + ) and draw the output waveform

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The next step in the model is to calculate the equilib^ rium condition q, or the allelic frequency when there is no change in allelic frequency from one generation to the next that is, when q (equation 20.3) is equal to zero: q Thus, pn Then, substituting (1 qn 1

characteristics of op amps is known as a comparator One particularly simple example known as a window comparator is shown in Figures P1565(a) and (b) Show that Vout = 0 whenever Vlow < Vin < Vhigh and that Vout = +V otherwise

(20.5)

Fig 759: A Toshiba ultra-precision grinding machine [26]

the op-amp be an LM741 with 15 V bias supplies, and suppose RF is chosen to be 104 k Assume Vin is a 1-kHz sinusoidal signal with 1-V amplitude a Determine the appropriate value for Rin if the output is to be high whenever |Vin | 025 V b Sketch the input and output waveforms

(20.4)

peak sine wave at 5 kHz, R = 10 k , and D1 and D2 are 62-V Zener diodes Draw the output voltage waveform

(728)

or, by rearranging:

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