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Scientists claim that genetic research will explain interindividual variation of the therapeutic effectiveness and toxicity of drugs (Meyer, 2000). Genetic tests will, they say, result in safer and ef cient pharmacotherapy (Ingelman-Sundberg, 2001) by enabling physicians to more precisely select medications and dosages that are optimal for individual patients (Evans and Relling, 1999). Scientists at a leading pharmaceutical company state that genetic pro ling of patients risks may help reduce the number of admissions to hospital that arise because of adverse drug reactions and interactions (Fears et al., 2000). A scientist at another large pharmaceutical company predicted, We will soon be able to pro le variations between individuals DNA to predict responses to a particular medicine. . . . [This] will change the practice and economics of medicine (Roses, 2000b). As the genetic revolution comes to fruition, writes one representative of a biotechnology company, there will be no need to wait until a patient gets sick: Shortly after a person is born, her genotype is recorded at her physician s of ce. . . . Assisted by a decision support system, her physician may prescribe a personal immunization and screening schedule or recommend speci c preventive measures (Sander, 2000). The editor of this volume wrote:

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It is important to understand that the home team is worthy of careful inspection as well as the opposition . For example, two nations that are partners in a new weapon system development project may seem to want the same thing, but one may be desperate for completion by the agreed date and the other may prefer signi cant delay. Those party to the negotiation of the agreements between the two countries may understand this very clearly, but those implementing the contract may not, with obvious implications. A few pages of background to the agreement making such issues clear to everyone involved can be very valuable. Complex relationships may bene t from formal exploration using the identi cation methodologies discussed in 7. An essential deliverable of the de ne phase is a comprehensive list of all the players who may prove central to the project. The purpose is to provide suf cient detail for following steps and suf cient summary information to trigger later recognition of sources of uncertainty that can be generated by all parties to the project.

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Temperature ( C)

They are both certain the trade will go through at the agreed-upon $12 Since there is no actual trade of an asset at the point the forward contract is agreed upon, forward contracts are called derivatives The value of a forward contract does not come from its own intrinsic worth; instead, it derives from its ability to transform (postpone) the trade of Company X s shares (from Jack to Jill) into a future trade with a certain price Company X stock would then be the underlying asset from which the forward contract derives its value In our simple example we have a forward contract with two fortunate individuals who coincidentally found an investor with the exact opposite needs In the market for forward contracts, however, there may be a preponderance of investors on one side or another, which would push the forward price away from its expected value.

(7.18) (7.19)

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Sit comfortably, preferably in a quiet place without too many distractions. If possible, sit with upright posture aligning your head over your heart. Close your eyes, if possible, to help concentration. If not, just look into the distance with a softened, nonfocused gaze. Determine the length of the session. Typically, it will range from 5 to 20 minutes for the entire cycle with approximately equal time given to each contact step. Settle in by taking a few deep relaxing breaths and slowly letting them out: Step 1. Establish and maintain simple contact with your body sensations. As a physical sensation arises in your body, carefully

0 10 Methane flux (%) 20 30 40 50 60 0 2 4 6 8 10 12 14 16 Temperature ( C) 0 10 Methane flux (%) 20 30 40 50 60 12 y = 2.5863x 25.755 r 2 = 0.2425 y = 1.9523x 54.766 r 2 = 0.3014

project that I think has real benefits. So nowadays I try to keep in mind that I need to slow down to avoid bulldozing others. When I m under pressure, I know that I can get a little uncommunicative. If I ve got too much to do, I like to get my head down and get on with it. So on those rare occasions, people have said that I m not my usually fun self. But when I ve got the work out of the way, I quickly snap out of it.

A market consisting of sellers (like Jack) would be delighted to receive the full price of $12, but some sellers may also be willing to receive a little less (sell at a discount) in order to eliminate risk How much less they would be willing to receive will depend on how fearful they are of risk of receiving much less than $12 on the maturity date It is all a matter of how risk averse they are (For a discussion of risk aversion, see 6) There will be very few investors willing to take a substantial discount, but as the discount is reduced, more investors will be willing to trade See the righthand side panel of Figure 311.

8.4 AUTOMATED END-TO-END SERVICE QUALITY ASSURANCE IN MANETS An important aspect of performance management in MANETs is the provision of service assurances to high-priority applications, sometimes at the expense of lower-priority applications. This section provides some background about this problem, including the particular challenges in providing end-toend service quality in MANETs. An approach to providing quality of service using dynamic throughput graphs [Poylisher et al., 2006] is discussed in detail. 8.4.1 Background