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In other words, the division of responsibility between manufacturers and providers for genetic risks will be determined by judges in response to population groups, rather than individuals, insisting that the liability system operate as a system of social control over the development and deployment of pharmacogenomics Caution does not mean we must shy away from addressing the ethical and legal quandaries that are just over the horizon, but we should be explicit about our assumptions as we move forward My four basic assumptions about the relationship of liability doctrines to pharmacogenomics are as follows First, the professional-patient relationship as viewed in liability, as opposed to contract doctrines (Schuck, 1994), is foundational to the ethical and social obligations of all participants in the institution of medicine, including those who produce, distribute, and prescribe the products of pharmacogenomics.

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1, which begins at zT-1 and goes to in nity The tail extrapolation involves mapping the interval [0, ) of the usual (standard) exponential with mean q = mT = 025x(T-1) + 075x(T) on the interval [zT-1, ) needed here and.

Each bidder estimates the value of the coins in the jar, and as bidding occurs he adjusts his estimate on the basis of what others say For example, if most bidders make higher bids than his own, a bidder might feel that he should increase his estimate of the value of the coins In this case, the winner generally over-estimates the value (since he has the highest estimate), and so it is likely that he pays more than the jar of coins is worth This is known as the winner s curse (about which we say more in Section 1417) Sometimes a bidder s valuation is a function of both private information and of information revealed during the auction For example, suppose an oil-lease is to be auctioned.

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Second, the liability of manufacturers of the products derived from pharmacogenomics will depend upon how courts, and perhaps legislatures, view the systemic relationship of professionals and pharmacogenomics producers Third, the initial introduction of pharmacogenomics will blur the distinction between liability doctrines associated with clinical treatment and research Fourth, scienti c descriptions of groups by their genotypes in the short run will not replace descriptions of individuals as members of distinct if not insular minorities or members of particular racial or ethnic groups It is apparent that pharmacogenomics creates a new way of assessing the risks and bene ts of drugs of all kinds at a point in time when systemic.

Closure Checklist I have always found that a closure checklist serves a useful purpose because it provides a quick summary of those project items that may require completion by the project manager. In order to achieve a proper closure on the project, the project manager should verify that the following questions have been answered. Have all the project objectives been achieved Is the client satisfied with the overall project Have the necessary post-project support agreements been established What were the major concerns with the project What are the key lessons learned from the IT project What would you do differently Do you feel the solution was cost effective When would it be applicable to enhance or update the delivered solution

The value of the lease depends both upon the amount of oil that is in the ground and the ef ciency with which it can be extracted Bidders may have different geological information about the likely amount of oil, and have different extraction ef ciencies, and so make different estimates of the value of the lease During bidding, bidders reveal information about their estimates and this may be helpful to other bidders There are many other considerations that come into play when designing auctions The seller may impose a participation fee, or a minimum reserve price An auction can be oral (bidders hear each other s bids and make counter-offers) or written (bidders submit closed sealed-bids in writing) In an oral auction, the number of bidders may be known, but in a sealed-bid auction the number is often unknown.

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