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Important consequences of obesity are type 2 diabetes and its associated metabolic and cardiovascular abnormalities, collectively termed the metabolic syndrome ( 10). The associations are partly explained by excess adiposity interfering with the ability of insulin to exert its normal metabolic and other actions so-called insulin resistance . The mechanisms through which obesity induces insulin resistance (or decreases insulin sensitivity) are described in detail in 10; suggested factors include raised levels of free fatty acid (FFA) and the ectopic deposition of triglyceride in key tissues such as liver and skeletal muscle. Insulin sensitivity is generally measured as insulin s impact on glucose metabolism, and particularly its ability to lower blood glucose concentrations, and this is the basis of the methods described below. However, insulin has many other actions including the suppression of very low density lipoprotein (VLDL) production by the liver, vasodilation and the stimulation of sympathetic tone and some of these effects may be impaired to different degrees (or even relatively spared) in individuals found to be insulin resistant by methods that assess glucose metabolism. Insulin lowers blood glucose both by inhibiting its endogenous production by the liver, and by decreasing its removal from the bloodstream, especially by skeletal muscle. The effect on the liver is quantitatively more important. Insulin inhibits both the processes that contribute to the glucose secreted into the bloodstream, that is, gluconeogenesis (the generation of glucose from other metabolites such as alanine, lactate and pyruvate) and glycogen breakdown (glycogenolysis). Hepatic glucose production maintains the normal fasting and basal blood glucose concentrations and is extremely insulin-sensitive: glucose output is constantly restrained by even low fasting levels of insulin, and is rapidly shut off when insulin concentrations increase after eating. The ability of insulin to suppress endogenous

There are many ways of looking at risks, from the riskiness of work items seen in the semiquantitative and tender evaluation examples in s 5 and 13 through to the detailed identification and inter-linkages seen in 18. In increasing complexity, they cover: riskiness of work items; lists of individual risks;

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1 L Baylor, et al Improved core fueling with high eld pellet injection in the DIII-D tokamak Phys Plasmas, 7:1878 1885, 2000 2 L Baylor, et al Comparison of fueling ef ciency from different fueling locations on DIII-D J Nucl Mater, 313:530 533, 2003 3 M Berger and J Oliger Adaptive mesh re nement for hyperbolic partial differential equations J Comput Phys, 53:484 512, 1984 4 MJ Berger and P Colella Local adaptive mesh re nement for shock hydrodynamics J Comput Phys, 82(1):64 84, 1989 5 P Colella Multidimensional upwind methods for hyperbolic conservation laws J Comput Phys, 87:171 200, 1990 6 P Colella, et al Chombo software package for AMR applications design document 7 RK Crockett, P Colella, R Fisher, RI Klein, and CF McKee An unsplit, cell-centered Godunov method for ideal MHD J Comput Phys, 203:422 448, 2005 8.

Cmf(w)

P Gohill, et al Investigations of H-mode plasmas triggered directly by pellet injection in the DIII-D tokamak Phys Rev Lett, 86:644 647, 2001 9 RJ Goldston and PH Rutherford Introduction to Plasma Physics Institute of Physics Publishing, Bristol, 1997 10 R Ishizaki, et al Two-dimensional simulation of pellet ablation with atomic processes Phys Plasmas, 11:4064 4080, 2004 11 SC Jardin, et al A fast shutdown technique for large tokamaks Nucl Fusion, 40:923 933, 2000 12 JB Bell, P Colella, JA Trangenstein, and M Welcome Adaptive mesh re nement on moving quadrilateral grids In Proceedings of the 9th AIAA Computational Fluid Dynamics Conference, Buffalo, NY, June 1989 13 BV Kuteev Hydrogen pellet ablation and acceleration by current in high temperature plasmas Nucl Fusion, 35:431 453, 1995 14 AK MacAulay.

The pairing or bonding process works by passing a protected passkey from one device to the other over an encrypted link. Depending on the security settings, you may not be able to make a direct connection. For example, you wouldn t normally leave on a device-to-device connection for personal address book or contact exchange. When you wanted to exchange the data, you would turn security off for the short time you were in range. If you see a message like Devices not found, device discovery may not be enabled. On some Bluetooth devices, depending on the manufacturer, there is a setting that turns on device discovery. If that setting is turned off, you will not be able to make that connection. Some Sony and Ericsson mobile phones have this feature on a discoverable menu.

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